Itgb1^tm1Ross
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm1Ross
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Robert S Ross
• MGI ID: MGI:2656179
• Synonyms: beta1^flox, beta1 integrin-floxed, Itgb1^f
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm1Ross page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82534
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted into intron 1 and intron 3 by homologous recombination. (J:82534)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 59 strains or lines available

References

• Original: J:82534 Shai SY, et al., Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 8;90(4):458-64
• All: 8 reference(s)