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Targeted Allele Detail
Symbol: Fbxo15tm1Yam
Name: F-box protein 15; targeted mutation 1, Shinya Yamanaka
MGI ID: MGI:2655776
Gene: Fbxo15  Location: Chr18:84952907-84999598 bp, + strand  Genetic Position: Chr18, 57.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:82741
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA beta-geo cassette replaced exons 3 through 7. The deleted region encoded the F box. Neither transript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice. The beta-galactosidase expression pattern was similar to that of the endogenous gene. (J:82741)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fbxo15 Mutation:  98 strains or lines available
Original:  J:82741 Tokuzawa Y, et al., Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol. 2003 Apr;23(8):2699-708
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory