Ilk^tm2Ref
Targeted Allele Detail

Summary

• Symbol: Ilk^tm2Ref
• Name: integrin linked kinase; targeted mutation 2, Reinhard Fassler
• MGI ID: MGI:2655774
• Synonyms: Ilk^-
• Gene: Ilk Location: Chr7:105385799-105392132 bp, + strand Genetic Position: Chr7, 55.97 cM, cytoband E1
• Alliance: Ilk^tm2Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were introduced into exon 1 and intron 2. Transient expression of cre recombinase in correctly targeted ES cells facilicated the removal of the floxed region (part of exon 1 and entire exon 2). (J:82761)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ilk Mutation: 18 strains or lines available

References

• Original: J:82761 Sakai T, et al., Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 2003 Apr 1;17(7):926-40
• All: 1 reference(s)