Hs3st1^tm1Nws
Targeted Allele Detail

Summary

• Symbol: Hs3st1^tm1Nws
• Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1; targeted mutation 1, Nicholas W Shworak
• MGI ID: MGI:2655749
• Synonyms: Hs3st1^-
• Gene: Hs3st1 Location: Chr5:39771278-39802935 bp, - strand Genetic Position: Chr5, 21.14 cM
• Alliance: Hs3st1^tm1Nws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82622
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 8 with a neomycin resistance cassette via homologous recombination. Enzymatic activity was nearly absent in plasma, heart, lung, and brain samples taken from homozygous mutant mice. (J:82622)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hs3st1 Mutation: 18 strains or lines available

References

• Original: J:82622 HajMohammadi S, et al., Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. J Clin Invest. 2003 Apr;111(7):989-99
• All: 2 reference(s)