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Hs3st1tm1Nws
Targeted Allele Detail
Nomenclature
Symbol: Hs3st1tm1Nws
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1; targeted mutation 1, Nicholas W Shworak
MGI ID: MGI:2655749
Synonyms: Hs3st1-
Gene: Hs3st1  Location: Chr5:39613935-39755475 bp, - strand  Genetic Position: Chr5, 21.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82622
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 8 with a neomycin resistance cassette via homologous recombination. Enzymatic activity was nearly absent in plasma, heart, lung, and brain samples taken from homozygous mutant mice. (J:82622)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hs3st1 Mutation:  7 strains or lines available
References
Original:  J:82622 HajMohammadi S, et al., Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. J Clin Invest. 2003 Apr;111(7):989-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory