Casp8^tm1Raz
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1Raz
• Name: caspase 8; targeted mutation 1, Razqallah Hakem
• MGI ID: MGI:2655730
• Synonyms: Casp8^fl, casp8^fl4-3
• Gene: Casp8 Location: Chr1:58834533-58886662 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1Raz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82759
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Resulting mutant animals carry loxP-flanked exons 3-4. (J:82759)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 42 strains or lines available

References

• Original: J:82759 Salmena L, et al., Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 2003 Apr 1;17(7):883-95
• All: 31 reference(s)