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Targeted Allele Detail
Symbol: Casp8tm1Raz
Name: caspase 8; targeted mutation 1, Razqallah Hakem
MGI ID: MGI:2655730
Synonyms: Casp8fl, casp8fl4-3
Gene: Casp8  Location: Chr1:58795374-58847503 bp, + strand  Genetic Position: Chr1, 29.19 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:82759
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Resulting mutant animals carry loxP-flanked exons 3-4. (J:82759)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp8 Mutation:  5 strains or lines available
Original:  J:82759 Salmena L, et al., Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 2003 Apr 1;17(7):883-95
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory