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Camk2atm1Vyb
Targeted Allele Detail
Nomenclature
Symbol: Camk2atm1Vyb
Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, Vadim Y Bolshakov
MGI ID: MGI:2655688
Synonyms: falpha-CaMKII KO
Gene: Camk2a  Location: Chr18:60925618-60988152 bp, + strand  Genetic Position: Chr18, 34.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82744
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was introduced into intron 1 and an frt/loxP-flanked neo cassette was introduced to intron 2 via homologous recombination. The neo cassette was removed by transient expression of flp recombinase in correctly targeted ES cells. Resulting mutant mice carry a floxed exon 2 allele. (J:82744)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Camk2a Mutation:  61 strains or lines available
References
Original:  J:82744 Hinds HL, et al., Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4275-80
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory