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Slc1a1tm1Wst
Targeted Allele Detail
Nomenclature
Symbol: Slc1a1tm1Wst
Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; targeted mutation 1, Wilheim Stoffel
MGI ID: MGI:2655190
Synonyms: eaac-1 -, EAAC1-, EAAT3-
Gene: Slc1a1  Location: Chr19:28835166-28913960 bp, + strand  Genetic Position: Chr19, 23.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41613
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 1 by homologous recombination. Northern blot analysis demonstrated that no detectable mRNA was expressed from this allele. (J:41613)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc1a1 Mutation:  2 strains or lines available
References
Original:  J:41613 Peghini P, et al., Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 1997 Jul 1;16(13):3822-32
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory