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Tlx2tm1Sjk
Targeted Allele Detail
Nomenclature
Symbol: Tlx2tm1Sjk
Name: T cell leukemia, homeobox 2; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:2655186
Synonyms: Enx-, Hox11L1-
Gene: Tlx2  Location: Chr6:83068324-83070293 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40722
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5' portion of exon 1, including the start codon, was replaced with a neomycin selection cassette inserted by homologous recombination. (J:40722)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlx2 Mutation:  6 strains or lines available
Notes
ES cell line = RW-4 (129X1/SvJ) or GS1 (129/Sv); see J:40722.
References
Original:  J:40722 Shirasawa S, et al., Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon. Nat Med. 1997 Jun;3(6):646-50
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2018
MGI 6.12
The Jackson Laboratory