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Aqp5tm1Amn
Targeted Allele Detail
Nomenclature
Symbol: Aqp5tm1Amn
Name: aquaporin 5; targeted mutation 1, Anil G Menon
MGI ID: MGI:2655164
Synonyms: Aqp5-
Gene: Aqp5  Location: Chr15:99591028-99594829 bp, + strand  Genetic Position: Chr15, 56.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82588
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 600 bp fragment encompassing exon 3 and surrounding intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded extracellular loop E, which contains the conserved Asn-Pro-Ala motif and the merucury-sensitive cysteine at position 182. Neither transcript nor protein was by analyses of salivary glands obtained from homozygous mutant mice. (J:82588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp5 Mutation:  8 strains or lines available
References
Original:  J:82588 Krane CM, et al., Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem. 2001 Jun 29;276(26):23413-20
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory