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Targeted Allele Detail
Symbol: Bcl2l1tm1Tak
Name: BCL2-like 1; targeted mutation 1, Junji Takeda
MGI ID: MGI:2654939
Synonyms: Bcl-xflox
Gene: Bcl2l1  Location: Chr2:152780668-152831728 bp, - strand  Genetic Position: Chr2, 75.41 cM, cytoband H1
Germline Transmission:  Earliest citation of germline transmission: J:82661
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was introduced upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. The floxed neo cassette was subsequently removed by mating mutant animals to cre deleter strain TgN(EIIa-cre)C5379Lmgd, resulting in animals carrying floxed exon 1-2 alleles. (J:82661)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l1 Mutation:  118 strains or lines available
Original:  J:82661 Umeda J, et al., In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis. FASEB J. 2003 Apr;17(6):610-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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