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Cd4tm1Nik
Targeted Allele Detail
Nomenclature
Symbol: Cd4tm1Nik
Name: CD4 antigen; targeted mutation 1, Nigel Kileen
MGI ID: MGI:2654930
Synonyms: Cd4lox
Gene: Cd4  Location: Chr6:124864692-124888221 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73479
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites were inserted upstream of the initiator methionine codon in exon 2 and in intron 3. (J:73479)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:  65 strains or lines available
References
Original:  J:73479 Wang Q, et al., Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. J Exp Med. 2001 Dec 17;194(12):1721-30
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory