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Targeted Allele Detail
Symbol: Plcb4tm1Tyo
Name: phospholipase C, beta 4; targeted mutation 1, Tohru Yoshioka
MGI ID: MGI:2654917
Gene: Plcb4  Location: Chr2:135659011-136014593 bp, + strand  Genetic Position: Chr2, 66.64 cM
Germline Transmission:  Earliest citation of germline transmission: J:104142
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons encoding amimo acids 539-646 were deleted and replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant mice was confirmed by Western blot analysis of brain proteins. (J:72939, J:104142)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plcb4 Mutation:  99 strains or lines available
Original:  J:104142 Sugiyama T, et al., Localization of phospholipase Cbeta isozymes in the mouse cerebellum. Biochem Biophys Res Commun. 1999 Nov 19;265(2):473-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory