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Targeted Allele Detail
Symbol: Aprttm1Vri
Name: adenine phosphoribosyl transferase; targeted mutation 1, Harry Vrieling
MGI ID: MGI:2654615
Synonyms: Aprt-
Gene: Aprt  Location: Chr8:122574635-122576909 bp, - strand  Genetic Position: Chr8, 71.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:50874
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of the promoter region with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by enzyme assay. Blood from homozygous mutant animals did not contain enzyme activity. (J:50874)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aprt Mutation:  12 strains or lines available
Original:  J:50874 Van Sloun PP, et al., Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice. Nucleic Acids Res. 1998 Nov 1;26(21):4888-94
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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