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Nkx2-5tm1(cre)Rjs
Targeted Allele Detail
Nomenclature
Symbol: Nkx2-5tm1(cre)Rjs
Name: NK2 homeobox 5; targeted mutation 1, Robert J Schwartz
MGI ID: MGI:2654594
Synonyms: Nkx2.5cre, Nkx2-5Cre, Nkx2-5/Cre, Nkx2.5-Cre
Gene: Nkx2-5  Location: Chr17:26838664-26844995 bp, - strand  Genetic Position: Chr17, 13.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73654
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cre recombinase gene followed by a neomycin selection cassette was inserted in-frame into exon 2. Reporter expression assays indicated that an active fusion protein was expressed from this allele in the embryonic heart, tongue, thymus and spleen. (J:73654)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx2-5     Summary of all recombinase alleles driven by Nkx2-5. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 37 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  14 strains or lines available
References
Original:  J:73654 Moses KA, et al., Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice. Genesis. 2001 Dec;31(4):176-80
All:  127 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory