Tg(Myh6-Gnaq)25Gwd
Transgene Detail

Summary

• Symbol: Tg(Myh6-Gnaq)25Gwd
• Name: transgene insertion 25, Gerald W Dorn II
• MGI ID: MGI:2654360
• Synonyms: alphaMHC-Gq, Galpha1-25, Tg(Myh6-Gnaq)1Gwd, Tg(Myhca-Gnaq)1Gwd
• Transgene: Tg(Myh6-Gnaq)25Gwd Location: unknown
• Alliance: Tg(Myh6-Gnaq)25Gwd page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Gnaq)25Gwd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gnaq (MGI:95776)

• Mutation details: A 1.46 kb mouse Gnaq cDNA sequence under regulatory control of a full length mouse Myhca promoter was used for the transgene. The mouse Myhca promoter was used to drive transgene expression in the heart. Transgenic line designated Galphaq-25 carries 25 copies of the transgene and exhibits 4-fold overexpression of the transgene product. (J:41949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:41949 D'Angelo DD, et al., Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8121-6
• All: 12 reference(s)