About   Help   FAQ
Cav1tm1Tt
Targeted Allele Detail
Nomenclature
Symbol: Cav1tm1Tt
Name: caveolin 1, caveolae protein; targeted mutation 1, Timothy C Thompson
MGI ID: MGI:2654177
Synonyms: cav-1-, Cav1-
Gene: Cav1  Location: Chr6:17306335-17341452 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82490
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette and loxP site were introduced flanking exon 2 via homologous recombination. Transient expression of cre-recombinase in correctly targeted ES cells resulted in deletion of exon 2 and the neo cassette leaving behind a single loxP site. Absence of protein product in homozygous mutant animals was confirmed by Western blot anlysis of heart, spleen, and lung extracts. (J:82490)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:  16 strains or lines available
References
Original:  J:82490 Cao G, et al., Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol. 2003 Apr;162(4):1241-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/13/2017
MGI 6.10
The Jackson Laboratory