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Targeted Allele Detail
Symbol: Cav1tm1Tt
Name: caveolin 1, caveolae protein; targeted mutation 1, Timothy C Thompson
MGI ID: MGI:2654177
Synonyms: cav-1-, Cav1-
Gene: Cav1  Location: Chr6:17306335-17341452 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:82490
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette and loxP site were introduced flanking exon 2 via homologous recombination. Transient expression of cre-recombinase in correctly targeted ES cells resulted in deletion of exon 2 and the neo cassette leaving behind a single loxP site. Absence of protein product in homozygous mutant animals was confirmed by Western blot anlysis of heart, spleen, and lung extracts. (J:82490)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:  17 strains or lines available
Original:  J:82490 Cao G, et al., Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol. 2003 Apr;162(4):1241-8
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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