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Nr1h3tm1.1Gstr
Targeted Allele Detail
Nomenclature
Symbol: Nr1h3tm1.1Gstr
Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, Gertrud Schuster
MGI ID: MGI:2653344
Synonyms: LXRalpha-
Gene: Nr1h3  Location: Chr2:91184061-91202829 bp, - strand  Genetic Position: Chr2, 50.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82096
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is derived from Nr1hrtm1Gstr. Exons 4 and 5 were deleted by mating Nr1h3tm1Gstr animals to cre deleter strain TgN(CMV-cre)1Cgn. Northern blot analysis of liver RNA from homozygous mutant animals detected a mutant transcript lacking 500 nucleotides corresponding to exons 4 and 5. (J:82096)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h3 Mutation:  9 strains or lines available
References
Original:  J:82096 Alberti S, et al., Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001 Mar;107(5):565-73
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory