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Trpm5tm1Csz
Targeted Allele Detail
Nomenclature
Symbol: Trpm5tm1Csz
Name: transient receptor potential cation channel, subfamily M, member 5; targeted mutation 1, Charles S Zuker
MGI ID: MGI:2653340
Gene: Trpm5  Location: Chr7:142625266-142648379 bp, - strand  Genetic Position: Chr7, 88.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82314
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 15 through 19 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 5 transmembrane domains. Immunostaining demonstrated an absence of normal protein in homozygous mutant taste buds. (J:82314)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpm5 Mutation:  37 strains or lines available
References
Original:  J:82314 Zhang Y, et al., Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003 Feb 7;112(3):293-301
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory