Nr1h3^tm1Gstr
Targeted Allele Detail

Summary

• Symbol: Nr1h3^tm1Gstr
• Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1, Gertrud Schuster
• MGI ID: MGI:2653320
• Synonyms: LXRalpha^hyp, LXR^hyp
• Gene: Nr1h3 Location: Chr2:91014406-91033179 bp, - strand Genetic Position: Chr2, 50.52 cM
• Alliance: Nr1h3^tm1Gstr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82096
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 3 and a neo-loxP cassette was inserted downstream of exon 5 via homologous recombination. (J:82096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h3 Mutation: 32 strains or lines available

References

• Original: J:82096 Alberti S, et al., Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001 Mar;107(5):565-73
• All: 4 reference(s)