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Targeted Allele Detail
Symbol: Tlr3tm1Flv
Name: toll-like receptor 3; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2653138
Synonyms: TLR-, Tlr3-, TLR3
Gene: Tlr3  Location: Chr8:45848702-45864112 bp, - strand  Genetic Position: Chr8, 25.31 cM, cytoband B2
Alliance: Tlr3tm1Flv page
Germline Transmission:  Earliest citation of germline transmission: J:72167
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 1 with a floxed neo cassette via homologous recombination. Northern blot analysis detected a truncated transcript in mutant animals. The mutant transcript does not encode a functional protein. (J:72167)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Tlr3 Mutation:  44 strains or lines available
Original:  J:72167 Alexopoulou L, et al., Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8
All:  210 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory