About   Help   FAQ
Tlr3tm1Flv
Targeted Allele Detail
Summary
Symbol: Tlr3tm1Flv
Name: toll-like receptor 3; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2653138
Synonyms: TLR-, Tlr3-, TLR3
Gene: Tlr3  Location: Chr8:45848702-45864112 bp, - strand  Genetic Position: Chr8, 25.31 cM, cytoband B2
Alliance: Tlr3tm1Flv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72167
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 with a floxed neo cassette via homologous recombination. Northern blot analysis detected a truncated transcript in mutant animals. The mutant transcript does not encode a functional protein. (J:72167)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Tlr3 Mutation:  44 strains or lines available
References
Original:  J:72167 Alexopoulou L, et al., Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8
All:  210 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/22/2022
MGI 6.22
The Jackson Laboratory