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Cdontm2Rsk
Targeted Allele Detail
Nomenclature
Symbol: Cdontm2Rsk
Name: cell adhesion molecule-related/down-regulated by oncogenes; targeted mutation 2, Robert S Krauss
MGI ID: MGI:2653132
Synonyms: CdonlacZ-2
Gene: Cdon  Location: Chr9:35421124-35507652 bp, + strand  Genetic Position: Chr9, 20.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82221
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-lacZ-neo cassette was inserted at the 3' terminus of exon 3. Endogenous protein was undetected by Western blot analysis of homozygous mutant mice. Beta-galactosidase activity was detected by staining. (J:82221)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdon Mutation:  7 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Holoprosencephaly in mice homozygous for Cdontm2Rsk (J:82221)

References
Original:  J:82221 Cole F, et al., Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon. Curr Biol. 2003 Mar 4;13(5):411-5
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory