Hcar2^tm1Soff
Targeted Allele Detail

Summary

• Symbol: Hcar2^tm1Soff
• Name: hydroxycarboxylic acid receptor 2; targeted mutation 1, Stefan Offermanns
• MGI ID: MGI:2653103
• Synonyms: Gpr109a^-, Hca2^-, Pumag^-
• Gene: Hcar2 Location: Chr5:124001633-124003562 bp, - strand Genetic Position: Chr5, 63.24 cM, cytoband F
• Alliance: Hcar2^tm1Soff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82225
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The majority of the protein coding region was replaced by a cassette containing lacZ and floxed neo. (J:82225)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcar2 Mutation: 21 strains or lines available

References

• Original: J:82225 Tunaru S, et al., PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med. 2003 Mar;9(3):352-5
• All: 48 reference(s)