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Targeted Allele Detail
Symbol: Abcc1tm1Acs
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1; targeted mutation 1, Alan C Sartorelli
MGI ID: MGI:2653091
Synonyms: mrp(-)
Gene: Abcc1  Location: Chr16:14361453-14474878 bp, + strand  Genetic Position: Chr16, 9.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:44305
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 0.7 kb genomic fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included sequence encoding a portion of the B motif of the putative ATP-binding domain. Protein was undetected by Western blot analysis of homozygous mutant mice. (J:44305)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcc1 Mutation:  11 strains or lines available
Original:  J:44305 Lorico A, et al., Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res. 1997 Dec 1;57(23):5238-42
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory