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Ndntm1.1Mus
Targeted Allele Detail
Nomenclature
Symbol: Ndntm1.1Mus
Name: necdin; targeted mutation 1.1, Francoise Muscatelli
MGI ID: MGI:2653064
Gene: Ndn  Location: Chr7:62348277-62349928 bp, + strand  Genetic Position: Chr7, 34.36 cM, cytoband C
Increased apoptosis in the dorsal root ganglias of Ndntm1.1Mus/Ndn+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66557
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe 5' two-thirds of the endogenous coding region was replaced with a floxed neo cassette inserted by homologous recombination. The neo cassette was then excised via cre-mediated recombination. (J:66557)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndn Mutation:  2 strains or lines available
References
Original:  J:66557 Muscatelli F, et al., Disruption of the mouse necdin gene results in hypothalamic and behavioral alterations reminiscent of the human prader-willi syndrome. Hum Mol Genet. 2000 Dec 12;9(20):3101-10
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory