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Ndntm1Stw
Targeted Allele Detail
Nomenclature
Symbol: Ndntm1Stw
Name: necdin; targeted mutation 1, Colin L Stewart
MGI ID: MGI:2653045
Gene: Ndn  Location: Chr7:62348277-62349928 bp, + strand  Genetic Position: Chr7, 34.36 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57890
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe majority of the protein coding region of endogenous allele was replaced with a cassette containing lacZ and floxed neo. 31 5' codons were left intact. The expression pattern of lacZ differed from the expression pattern observed for Ndntm2Stw, which lacked the floxed neo sequence. (J:57890)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndn Mutation:  2 strains or lines available
References
Original:  J:57890 Gerard M, et al., Disruption of the mouse necdin gene results in early post-natal lethality [see comments]. Nat Genet. 1999 Oct;23(2):199-202
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory