Ogg1^tm1Yun
Targeted Allele Detail

Summary

• Symbol: Ogg1^tm1Yun
• Name: 8-oxoguanine DNA-glycosylase 1; targeted mutation 1, Yusaku Nakabeppu
• MGI ID: MGI:2653014
• Synonyms: Ogg1^-, Ogg1^tm1Skmi
• Gene: Ogg1 Location: Chr6:113303959-113311149 bp, + strand Genetic Position: Chr6, 52.75 cM, cytoband E-F1
• Alliance: Ogg1^tm1Yun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82287
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a 3.1 kb genomic region encompassing exons 1-3 with a neomycin resistance cassette. RT-PCR analysis of liver RNA confirmed the absence of gene expression in homozygous mutant animals. (J:82287)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ogg1 Mutation: 23 strains or lines available

References

• Original: J:82287 Sakumi K, et al., Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res. 2003 Mar 1;63(5):902-5
• All: 16 reference(s)