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Targeted Allele Detail
Symbol: Slpitm1Nkw
Name: secretory leukocyte peptidase inhibitor; targeted mutation 1, Toshihiro Nukiwa
MGI ID: MGI:2652666
Synonyms: SLPI-/-
Gene: Slpi  Location: Chr2:164354070-164356507 bp, - strand  Genetic Position: Chr2, 85.16 cM, cytoband H
Germline Transmission:  Earliest citation of germline transmission: J:82214
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of all 4 exons with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis. (J:82214)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slpi Mutation:  11 strains or lines available
Original:  J:82214 Nakamura A, et al., Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice. J Exp Med. 2003 Mar 3;197(5):669-74
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory