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Apptm1.1Cep
Targeted Allele Detail
Nomenclature
Symbol: Apptm1.1Cep
Name: amyloid beta (A4) precursor protein; targeted mutation 1.1, Cephalon Inc
MGI ID: MGI:2652346
Synonyms: APPdeltaNL, APPNLH, APPsweKI
Gene: App  Location: Chr16:84954440-85173707 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35500
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:  14 strains or lines available
References
Original:  J:35500 Reaume AG, et al., Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a humanized Abeta sequence. J Biol Chem. 1996 Sep 20;271(38):23380-8
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory