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Targeted Allele Detail
Symbol: Pvalbtm1Swal
Name: parvalbumin; targeted mutation 1, Beat Schwaller
MGI ID: MGI:2652272
Synonyms: PV-
Gene: Pvalb  Location: Chr15:78191114-78206400 bp, - strand  Genetic Position: Chr15, 36.93 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:53121
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA fragment encompassing a portion of exon 2 and all of exons 3 and 4 was replaced with a PGK-neo cassette inserted by homologous recombination. Approximately 85% (nt 25 to 304) of the coding region was deleted. No protein was detected by Western blot analysis of various skelelal muscle tissue samples obtained from homozygous mutant mice. (J:53121)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pvalb Mutation:  24 strains or lines available
Original:  J:53121 Schwaller B, et al., Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice. Am J Physiol. 1999 Feb;276(2 Pt 1):C395-403
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory