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Targeted Allele Detail
Symbol: Ldb3tm1Chen
Name: LIM domain binding 3; targeted mutation 1, Ju Chen
MGI ID: MGI:2652058
Synonyms: cypher-
Gene: Ldb3  Location: Chr14:34526603-34588682 bp, - strand  Genetic Position: Chr14, 20.83 cM, cytoband B
Ventricular dilation in Ldb3tm1Chen/Ldb3tm1Chen hearts

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:72799
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1 kb fragment containing a portion of both exon 1 and intron 1 was replaced with a lacZ-neo cassette inserted by homologous recombination. No protein was detected by Western blot analysis of homozygous mutant heart tissue. Expression of the beta-galactosidase was driven by the endogenous promoter. (J:72799)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldb3 Mutation:  28 strains or lines available
Original:  J:72799 Zhou Q, et al., Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy. J Cell Biol. 2001 Nov 12;155(4):605-12
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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