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Nr3c1tm1Ljm
Targeted Allele Detail
Nomenclature
Symbol: Nr3c1tm1Ljm
Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1, Louis J Muglia
MGI ID: MGI:2651864
Synonyms: GRko, GRnull
Gene: Nr3c1  Location: Chr18:39410545-39519421 bp, - strand  Genetic Position: Chr18, 21.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82174
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 1C and 2 were deleted via homologous recombination followed by in vitro cre mediated recombination. Protein was undetected by Western blot analysis of homozygous mutant liver tissue. (J:82174)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:  21 strains or lines available
References
Original:  J:82174 Brewer JA, et al., Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol. 2002 Aug 15;169(4):1837-43
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory