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Wasltm1.1Sbs
Targeted Allele Detail
Nomenclature
Symbol: Wasltm1.1Sbs
Name: Wiskott-Aldrich syndrome-like (human); targeted mutation 1.1, Scott B Snapper
MGI ID: MGI:2651838
Synonyms: N-WASP-, Wastm2.1Sbs
Gene: Wasl  Location: Chr6:24613805-24665009 bp, - strand  Genetic Position: Chr6, 11.28 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72053
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed neo cassette that had replaced exon 2 was excised when mice carrying Wasltm1Sbs were mated with transgenic mice expressing cre recombinase in the germline. Normal protein was undetected by Western blot analysis of extracts obtained from homozygous mutant ES cells. (J:72053)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wasl Mutation:  28 strains or lines available
References
Original:  J:72053 Snapper SB, et al., N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct;3(10):897-904
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory