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Targeted Allele Detail
Symbol: Lpltm1Bres
Name: lipoprotein lipase; targeted mutation 1, Jan L Breslow
MGI ID: MGI:2651805
Synonyms: L1, LPL-
Gene: Lpl  Location: Chr8:69333207-69359584 bp, + strand  Genetic Position: Chr8, 33.88 cM
Gross pathology of Lpltm1Bres/Lpltm1Bres pups at 14-16 hours after birth

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:30062
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encompassing a portion of exon 1, including the start codon and signal sequence, and all of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Lipoprotein lipase activity was shown to be almost completely ablated in homozygous mutant mice. (J:30062)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lpl Mutation:  32 strains or lines available
Original:  J:30062 Weinstock PH, et al., Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest. 1995 Dec;96(6):2555-68
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory