About   Help   FAQ
Erbb2tm1Vrtn
Targeted Allele Detail
Summary
Symbol: Erbb2tm1Vrtn
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Timothy Vartanian
MGI ID: MGI:2651799
Synonyms: erbB2-
Gene: Erbb2  Location: Chr11:98303310-98328542 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance: Erbb2tm1Vrtn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71775
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing the exon encoding the essential transmembrane domain and portions of both the extracellular and cytomplasmic domains was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis detected reduced levels of protein in heterozygous embryos and no normal protein in homozygous embryos. (J:71775)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  59 strains or lines available
References
Original:  J:71775 Park SK, et al., The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. J Cell Biol. 2001 Sep 17;154(6):1245-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory