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Erbb2tm1Vrtn
Targeted Allele Detail
Nomenclature
Symbol: Erbb2tm1Vrtn
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Timothy Vartanian
MGI ID: MGI:2651799
Synonyms: erbB2-
Gene: Erbb2  Location: Chr11:98412470-98437716 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71775
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing the exon encoding the essential transmembrane domain and portions of both the extracellular and cytomplasmic domains was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis detected reduced levels of protein in heterozygous embryos and no normal protein in homozygous embryos. (J:71775)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  21 strains or lines available
References
Original:  J:71775 Park SK, et al., The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. J Cell Biol. 2001 Sep 17;154(6):1245-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory