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Transgene Detail
Symbol: Tg(K5-Ptgs2)667Kmd
Name: transgene insertion 667, Karin Muller-Decker
MGI ID: MGI:2651675
Synonyms: K5.COX-2/667
Transgene: Tg(K5-Ptgs2)667Kmd  Location: unknown  
Sparse hair and long nails in mice expressing Tg(K5-Ptgs2)

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  NMRI
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(K5-Ptgs2)667Kmd expresses 1 gene
Mutation detailsThe transgene is composed of a full length Ptgs2 cDNA without the 3' untranslated region fused to a bovine keratin 5 (K5) promoter. The bovine K5 promoter was used to drive transgene expression in basal keratinocytes of the interfollicular epidermis and in basal cells of the pilosebaceous unit. Transgene expression was observed in keratinocytes of the interfollicular stratum basale, the outer root sheath (ORS) cells of hair follicles, and the epithelial lining of sebaceous glands. Transgene expression was confirmed by RT-PCR analysis of stratified epithelial tissues. (J:70039)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Seven founder animals were constructed and bred successfully. The founders are designated lines 4, 19, 29, 663, 667, 675, and 678. Line 667 exhibits strong transgene expression.
Original:  J:70039 Neufang G, et al., Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7629-34
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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