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Ppargtm2Rev
Targeted Allele Detail
Nomenclature
Symbol: Ppargtm2Rev
Name: peroxisome proliferator activated receptor gamma; targeted mutation 2, Ronald M Evans
MGI ID: MGI:2651605
Synonyms: gf, PPARgammaf, PPARgammafl, Ppargflox
Gene: Pparg  Location: Chr6:115360951-115490399 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88210
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was introduced upstream of exon 1 and a floxed neomycin cassette was inserted downstream of exon 2. The neomycin gene was excised from correctly targeted ES cells by transient transfection with a Cre expression plasmid. (J:88210)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  26 strains or lines available
References
Original:  J:88210 He W, et al., Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15712-7
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory