Tg(KRT5-cre/PGR)1Der
Transgene Detail

Summary

• Symbol: Tg(KRT5-cre/PGR)1Der
• Name: transgene insertion 1, Dennis R Roop
• MGI ID: MGI:2651408
• Synonyms: K5-Cre, K5-CrePR, K5CrePR1, K5.CrePR1
• Transgene: Tg(KRT5-cre/PGR)1Der Location: unknown
• Alliance: Tg(KRT5-cre/PGR)1Der page

Transgene origin

• Strain of Origin: (ICR x FVB)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Tg(KRT5-cre/PGR)1Der expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT5 (3852)

  Krt5	(MGI:96702)

• Mutation details: This transgene expresses a Cre recombinase and human progesterone receptor gene fusion under the control of a bovine keratin 5 promoter, active in the basal layer of the epidermis and hair follicles. (J:75280)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT5 (human) Summary of all recombinase alleles driven by KRT5. Comparative matrix view of recombinase activities Alliance human KRT5 gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT5-cre/PGR)1Der

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:75280 Zhou Z, et al., In utero activation of K5.CrePR1 induces gene deletion. Genesis. 2002 Feb;32(2):191-2
• All: 26 reference(s)