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Targeted Allele Detail
Symbol: Scn2btm1Isom
Name: sodium channel, voltage-gated, type II, beta; targeted mutation 1, Lori L Isom
MGI ID: MGI:2451362
Synonyms: Beta2-, Scn2btm1Lli
Gene: Scn2b  Location: Chr9:45117876-45130070 bp, + strand  Genetic Position: Chr9, 24.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:82050
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3, which encode the mature protein, were replaced with a neo cassette inserted by homologous recombination. Neither transcript nor protein were detected by Northern and Western blot analyses of homozygous mutant brain tissues. (J:82050)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn2b Mutation:  3 strains or lines available
Original:  J:82050 Chen C, et al., Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17072-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory