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Targeted Allele Detail
Symbol: Stat3tm1Flv
Name: signal transducer and activator of transcription 3; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2451328
Synonyms: STAT3f, STAT3KO
Gene: Stat3  Location: Chr11:100886806-100939579 bp, - strand  Genetic Position: Chr11, 63.82 cM
Crohn's disease-like pathogenesis in Stat3tm1Flv/Stat3tm1Flv Tg(Tek-cre)12Flv/0 mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81973
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 18 through 20 were flanked by single loxP sites in introns 17 and 20. The floxed exons encode the Src homology 2 domain. (J:81973)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:  36 strains or lines available
Original:  J:81973 Welte T, et al., STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory