Aldh1a2tm1Dll
Targeted Allele Detail
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Symbol: |
Aldh1a2tm1Dll |
Name: |
aldehyde dehydrogenase family 1, subfamily A2; targeted mutation 1, Pascal Dolle |
MGI ID: |
MGI:2451316 |
Synonyms: |
Raldh2neo |
Gene: |
Aldh1a2 Location: Chr9:71123071-71203525 bp, + strand Genetic Position: Chr9, 39.85 cM
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Alliance: |
Aldh1a2tm1Dll page
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Outflow tract septation defects and abnormal patterns of aortic arch-derived arteries in Aldh1a2tm1Dll/Aldh1a2tm1Dll and Aldh1a2tm1Dll/Aldh1a2tm1Ipc mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:81969
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Hypomorph) |
Mutation: |
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Insertion
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Mutation details: Exon 4 was flanked by a single loxP site in intron 3 and a floxed neo cassette in intron 4. This allele was shown to be hypomorphic by in situ hybridization and immunohistochemical analysis, which showed reduced levels of transcript and protein in homozygous mutant embyros.
(J:81969)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Aldh1a2 Mutation: |
36 strains or lines available
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Original: |
J:81969 Vermot J, et al., Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1763-8 |
All: |
19 reference(s) |
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