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Kcnc1tm1Joho
Targeted Allele Detail
Summary
Symbol: Kcnc1tm1Joho
Name: potassium voltage gated channel, Shaw-related subfamily, member 1; targeted mutation 1, Rolf H Joho
MGI ID: MGI:2451092
Synonyms: Kv3.1-
Gene: Kcnc1  Location: Chr7:46045921-46088128 bp, + strand  Genetic Position: Chr7, 30.1 cM
Alliance: Kcnc1tm1Joho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38598
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of 35 bp of the S2-S3 linker sequence with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain proteins. (J:38598)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnc1 Mutation:  39 strains or lines available
References
Original:  J:38598 Ho CS, et al., Pleiotropic effects of a disrupted K+ channel gene: reduced body weight, impaired motor skill and muscle contraction, but no seizures. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1533-8
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory