About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Fmr1tm2Cgr
Name: fragile X mental retardation syndrome 1; targeted mutation 2, Ben Oostra
MGI ID: MGI:2451086
Synonyms: CGG(98)
Gene: Fmr1  Location: ChrX:68678541-68717963 bp, + strand  Genetic Position: ChrX, 34.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:71202
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutation:    Nucleotide repeat expansion
Mutation detailsThe mouse promoter 8 CGG repeat sequence was replaced with a human 98 CGG repeat and a floxed neo cassette via homologous recombination. The targeted allele was verified by PCR analysis. Germline passage of this allele results in contraction and expansion of the CGG repeats. (J:71202)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:  21 strains or lines available
Original:  J:71202 Bontekoe CJ, et al., Instability of a (CGG)98 repeat in the Fmr1 promoter. Hum Mol Genet. 2001 Aug 1;10(16):1693-9
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory