Lipa^tm1Ggb
Targeted Allele Detail

Summary

• Symbol: Lipa^tm1Ggb
• Name: lysosomal acid lipase A; targeted mutation 1, Gregory A Grabowski
• MGI ID: MGI:2451080
• Synonyms: lal^-
• Gene: Lipa Location: Chr19:34469718-34504874 bp, - strand Genetic Position: Chr19, 29.7 cM
• Alliance: Lipa^tm1Ggb page

Lipid storage in the liver and small intestine and decrease in subcutaneous white adipose tissue in Lipa^tm1Ggb/Lipa^tm1Ggb mice as they age

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49674
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 5 with an HPRT cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analysis of liver homogenates. (J:49674)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lipa Mutation: 21 strains or lines available

References

• Original: J:49674 Du H, et al., Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage. Hum Mol Genet. 1998 Sep;7(9):1347-54
• All: 32 reference(s)