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Targeted Allele Detail
Symbol: Lipatm1Ggb
Name: lysosomal acid lipase A; targeted mutation 1, Gregory A Grabowski
MGI ID: MGI:2451080
Synonyms: lal-
Gene: Lipa  Location: Chr19:34469718-34504874 bp, - strand  Genetic Position: Chr19, 29.7 cM
Lipid storage in the liver and small intestine and decrease in subcutaneous white adipose tissue in Lipatm1Ggb/Lipatm1Ggb mice as they age

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:49674
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 5 with an HPRT cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analysis of liver homogenates. (J:49674)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lipa Mutation:  17 strains or lines available
Original:  J:49674 Du H, et al., Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage. Hum Mol Genet. 1998 Sep;7(9):1347-54
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory