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Itga1tm1Gdnr
Targeted Allele Detail
Summary
Symbol: Itga1tm1Gdnr
Name: integrin alpha 1; targeted mutation 1, Humphrey Gardner
MGI ID: MGI:2451067
Synonyms: alpha1-
Gene: Itga1  Location: Chr13:115094615-115238500 bp, - strand  Genetic Position: Chr13, 64.61 cM
Alliance: Itga1tm1Gdnr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32930
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette in the reverse orientation into a coding exon via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunoprecipitation immunoblot and immunohistochemical analysis. (J:32930)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga1 Mutation:  64 strains or lines available
References
Original:  J:32930 Gardner H, et al., Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. Dev Biol. 1996 May 1;175(2):301-13
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory