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Targeted Allele Detail
Symbol: Asic3tm1Pig
Name: acid-sensing (proton-gated) ion channel 3; targeted mutation 1, Andreas Zimmer
MGI ID: MGI:2451051
Synonyms: ASIC3-
Gene: Asic3  Location: Chr5:24413451-24417840 bp, + strand  Genetic Position: Chr5, 11.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:81785
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 2-11 with a lacZ-neo cassette via homologous recombination. The targeted mutation results in deletion of the second transmembrane domain as well as most of the extracellular domain. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of dorsal root ganglion cells using a probe to exon 1. (J:81785)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Asic3 Mutation:  21 strains or lines available
Original:  J:81785 Chen CC, et al., A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8992-7
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory