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S100btm1Ito
Targeted Allele Detail
Nomenclature
Symbol: S100btm1Ito
Name: S100 protein, beta polypeptide, neural; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:2451049
Gene: S100b  Location: Chr10:76253853-76261159 bp, + strand  Genetic Position: Chr10, 38.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81786
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 and part of exon 3 were replaced with a floxed neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot and immunohistochemical analysis. (J:81786)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S100b Mutation:  5 strains or lines available
References
Original:  J:81786 Nishiyama H, et al., Glial protein S100B modulates long-term neuronal synaptic plasticity. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4037-42
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory