S100b^tm1Ito
Targeted Allele Detail

Summary

• Symbol: S100b^tm1Ito
• Name: S100 protein, beta polypeptide, neural; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:2451049
• Gene: S100b Location: Chr10:76089687-76096993 bp, + strand Genetic Position: Chr10, 38.76 cM
• Alliance: S100b^tm1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81786
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 and part of exon 3 were replaced with a floxed neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot and immunohistochemical analysis. (J:81786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S100b Mutation: 14 strains or lines available

References

• Original: J:81786 Nishiyama H, et al., Glial protein S100B modulates long-term neuronal synaptic plasticity. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4037-42
• All: 8 reference(s)