Mchr1^tm1Sqn
Targeted Allele Detail

Summary

• Symbol: Mchr1^tm1Sqn
• Name: melanin-concentrating hormone receptor 1; targeted mutation 1, Su Qian
• MGI ID: MGI:2451034
• Synonyms: Mch1r^-, Mchr1 KO
• Gene: Mchr1 Location: Chr15:81119700-81123165 bp, + strand Genetic Position: Chr15, 38.02 cM
• Alliance: Mchr1^tm1Sqn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81787
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2 with a neomycin resistance cassette. The targeted mutation results in deletion of sequences spanning the first transmembrane domain to the stop codon. Absence of gene expression in homozygous mutant animals was confirmed by in situ hybridization analysis of coronal brain sections. (J:81787)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mchr1 Mutation: 24 strains or lines available

References

• Original: J:81787 Marsh DJ, et al., Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3240-5
• All: 11 reference(s)