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Targeted Allele Detail
Symbol: Msi1tm1Okn
Name: musashi RNA-binding protein 1; targeted mutation 1, Hideyuki Okano
MGI ID: MGI:2450917
Synonyms: msi1-
Gene: Msi1  Location: Chr5:115429599-115455698 bp, + strand  Genetic Position: Chr5, 56.09 cM, cytoband E3-F
Development of hydrocephalus in postnatal Msi1tm1Okn/Msi1tm1Okn mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81794
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacment of a 4.2 kb genomic region (encoding the translation initiation site and the first RNA recognition motif) with a neomycin resistance cassette via homologous recombination. Western blot analysis of embryonic and neonatal brain proteins confirmed the absence of gene expression in homozygous mutant animals. (J:81794)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Msi1 Mutation:  20 strains or lines available
Original:  J:81794 Sakakibara S, et al., RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15194-9
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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