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Targeted Allele Detail
Symbol: Tectm1Welm
Name: tec protein tyrosine kinase; targeted mutation 1, Wilfred Ellmeier
MGI ID: MGI:2450883
Synonyms: Tec-
Gene: Tec  Location: Chr5:72755716-72868483 bp, - strand  Genetic Position: Chr5, 38.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:66080
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin selection cassette disrupted the endogenous allele by replacing exon 2 and surrounding intronic sequence. The deleted exon contained the start codon, encoded 45 residues of the Pleckstrin homology domain, and is common to the 4 known isoforms. Western blot analysis showed an absence of full length and truncated protein. (J:66080)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tec Mutation:  25 strains or lines available
Original:  J:66080 Ellmeier W, et al., Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk. J Exp Med. 2000 Dec 4;192(11):1611-24
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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