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Targeted Allele Detail
Symbol: Tectm1Welm
Name: tec protein tyrosine kinase; targeted mutation 1, Wilfred Ellmeier
MGI ID: MGI:2450883
Synonyms: Tec-
Gene: Tec  Location: Chr5:72913059-73025826 bp, - strand  Genetic Position: Chr5, 38.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:66080
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin selection cassette disrupted the endogenous allele by replacing exon 2 and surrounding intronic sequence. The deleted exon contained the start codon, encoded 45 residues of the Pleckstrin homology domain, and is common to the 4 known isoforms. Western blot analysis showed an absence of full length and truncated protein. (J:66080)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tec Mutation:  28 strains or lines available
Original:  J:66080 Ellmeier W, et al., Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk. J Exp Med. 2000 Dec 4;192(11):1611-24
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory