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Soat2tm1Far
Targeted Allele Detail
Summary
Symbol: Soat2tm1Far
Name: sterol O-acyltransferase 2; targeted mutation 1, Bob Farese
MGI ID: MGI:2450875
Synonyms: ACAT2
Gene: Soat2  Location: Chr15:102058961-102071904 bp, + strand  Genetic Position: Chr15, 57.33 cM
Alliance: Soat2tm1Far page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82032
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of 1.5 kb of 3' sequences with a neomycin resistance cassette by homologous recombination. The gene targeting event results in deletion of 28% of the protein coding sequence. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of mRNA from liver and small intestines. (J:82032)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Soat2 Mutation:  39 strains or lines available
References
Original:  J:82032 Buhman KK, et al., Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat Med. 2000 Dec;6(12):1341-7
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory